ADAPs continue to play a critical role in efforts to end the domestic HIV epidemic by providing and maintaining access to medications for people living with HIV (PLWH). Effective antiretroviral therapy is associated with optimal health outcomes such as viral load suppression, which in turn greatly reduces HIV transmission and rates for new infections. Yet PLWH experience other health concerns beyond HIV, many of which also require access to medications and treatment. As ARVs have greatly extended the life expectancy of PLWH, other conditions that occur as a result of aging are increasingly important to address and treat. Finally, issues related to hepatitis, substance use and mental health pose challenges to PLWH in terms of their broader health and well-being and the overall effectiveness of ARV treatment.