West Virginia is in the midst of an unprecedented heroin and opioid epidemic that is disrupting the lives of not only individuals and families, but also entire communities and regions. A recent white paper developed by the West Virginia Association of Local Health Departments explores how local health departments (LHDs) are leading with a Public Health 3.0 approach to mitigate this public health crisis. By going beyond their traditional roles, recognizing the need to address societal factors affecting the health of the people in their communities, engaging in cross-sector partnerships, and exploring innovative funding models, these LHDs have proven to be essential partners in combating the state’s opioid and heroin epidemic. The result has been an increased capacity to provide compassionate care to people struggling with addiction and substance use disorders; move individuals toward recovery; use harm reduction to mitigate infectious risks of intravenous drug use; and save lives with naloxone training and distribution. Read the white paper to learn exactly how LHDs in West Virginia are leading the way to curb this public health crisis.