The Health Resources and Services Administration’s HIV/AIDS Bureau has released a letter in support of pre-exposure prophylaxis (PrEP) as a prevention tool against HIV transmission, to align with the National HIV/AIDS Strategy: Updated to 2020 (NHAS). Specifically, the letter supports NHAS Goal 1, Reduce new infections and calls upon federal agencies to implement PrEP within their programs, by encouraging Ryan White HIV/AIDS Program (RWHAP) recipients and providers to leverage the RWHAP infrastructure to support PrEP services within the parameters of the RWHAP legislation.